منابع مشابه
Mitochondrial DNA Damage and Diseases
Various endogenous and environmental factors can cause mitochondrial DNA (mtDNA) damage. One of the reasons for enhanced mtDNA damage could be its proximity to the source of oxidants, and lack of histone-like protective proteins. Moreover, mitochondria contain inadequate DNA repair pathways, and, diminished DNA repair capacity may be one of the factors responsible for high mutation frequency o...
متن کاملEpigenetics, epidemiology and mitochondrial DNA diseases.
Over the last two decades, the mutation of mitochondrial DNA (mtDNA) has emerged as a major cause of inherited human disease. The disorders present clinically in at least 1 in 10,000 adults, but pathogenic mutations are found in approximately 1 in 200 of the background population. Mitochondrial DNA is maternally inherited and there can be marked phenotypic variability within the same family. He...
متن کاملCurrent perspectives in the treatment of mitochondrial DNA diseases.
Defects of the mitochondrial genome are an important cause of genetic disease (1). The clinical features are very varied but in many individuals the defect leads to progressive problems which may result in severe disability and even death. It is against the background of increasing recognition and detection of mitochondrial DNA (mtDNA) disorders that clinicians and scientists must strive to dev...
متن کاملMitochondrial DNA as an inflammatory mediator in cardiovascular diseases
Mitochondria play a central role in multiple cellular functions, including energy production, calcium homeostasis, and cell death. Currently, growing evidence indicates the vital roles of mitochondria in triggering and maintaining inflammation. Chronic inflammation without microbial infection - termed sterile inflammation - is strongly involved in the development of heart failure. Sterile infla...
متن کاملMitochondrial Dynamics in Mitochondrial Diseases
Mitochondria are very versatile organelles in continuous fusion and fission processes in response to various cellular signals. Mitochondrial dynamics, including mitochondrial fission/fusion, movements and turnover, are essential for the mitochondrial network quality control. Alterations in mitochondrial dynamics can cause neuropathies such as Charcot-Marie-Tooth disease in which mitochondrial f...
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ژورنال
عنوان ژورنال: DNA and Cell Biology
سال: 2020
ISSN: 1044-5498,1557-7430
DOI: 10.1089/dna.2019.5220